with flowcytometry, cytogenetic and molecular biology findings
Novartis IBA FM MU

Acute promyelocytic leukaemia with NPM1-RARA

PB MGG (1000×)

One leukaemic promyelocyte – a kidney-shaped nucleus with fine, blastic appearance of chromatin, a less distinct nucleolus and numerous fine to coarser azurophilic granules obscuring the nucleus.

BM MGG (200×)

Hypercellular marrow aspirate smear with a prevailing leukaemic population of promyelocytes.

BM MGG (1000×)

Many leukaemic promyelocytes of different sizes, with different volumes of cytoplasm, various shapes of nuclei and numerous granules obscuring the nuclei. Many of these cells are disintegrated in this image, with their granules spilled out. The image also shows erythroblasts in different stages of maturation (cyan arrows) and a monocyte (yellow arrow).

BM MGG (1000×)

Many leukaemic promyelocytes with numerous granules, which obscure the nuclei almost completely.

Atlas of Haematological Cytology [online]. 2016 [cit. 2024-3-29]. Available from WWW: http://www.leukemia-cell.org/atlas.

2024 CELL - Atlas of Haematological Cytology | site map