Mixed cellularity classic Hodgkin lymphoma

The structure of the lymph node is almost totally effaced by the paracortex expanded by a tumour. Several large atypical cells and a very extensive admixture of eosinophilic leucocytes can be seen even in this low-power view.

Lymph node biopsy, haematoxylin and eosin stain.

The disperse large atypical Hodgkin/Reed-Sternberg (HRS) cells are present, one of them is binuclear with mirror-imaged vesicular nuclei and inclusion-like nucleoli, the features typical for diagnostic RS cell. The rich “inflammatory” background consists of small lymphocytes, plasma cells, disperse macrophages and a lot of eosinophils. 

Lymph node biopsy, haematoxylin and eosin stain.