Sickle cell anaemia

Marked anisopoikilocytosis, hypochromia and markedly atypical erythrocytes in terms of shape (numerous target cells, e.g. an erythrocyte marked by a white arrow). Sickle cells are marked by red arrows. A nucleated red blood cell – an erythroblast with a pyknotic nucleus – is shown in the middle of the image. Pappenheimer bodies, i.e. inclusion bodies composed of ferritin aggregates, are evident in some erythrocytes (marked by a black arrow).

Marked anisopoikilocytosis, hypochromia and markedly atypical erythrocytes in terms of shape. Sickle cells are marked by red arrows. A segmented neutrophil is shown in the middle of the image. An erythrocyte containing a Pappenheimer body is marked by a black arrow, and an early polychromatophilic erythroblast – a reticulocyte – is marked by a yellow arrow.

Marked anisopoikilocytosis, hypochromia and markedly atypical erythrocytes in terms of shape. Sickle cells are marked by red arrows. A segmented neutrophil is shown in the middle of the image. An erythrocyte containing a Howell–Jolly body is marked by a green arrow, and a mechanically damaged erythrocyte – a keratocyte – is marked by a cyan arrow.

Marked anisopoikilocytosis, hypochromia and markedly atypical erythrocytes in terms of shape. Sickle cells are marked by red arrows, and reticulocytes are marked by yellow arrows.