Beta thalassaemia major

Marked anisopoikilocytosis, anisohypochromia and markedly atypical erythrocytes (in terms of shape) are shown in this peripheral blood smear: for example, target cells (green), polychromasia (red) and, in the centre of the image, three oxyphilic erythroblasts containing pyknotic nuclei with irregular contours. A Howell–Jolly body is marked by a yellow arrow.